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KMID : 0361120080220020183
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Korean Journal of Transplantation
2008 Volume.22 No. 2 p.183 ~ p.196
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dipose Tissue Derived Mesenchymal Stem Cells
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Jung Jin-Sup
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Abstract
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esenchymal stem cells (MSCs) are a heterogeneous population of cells that proliferate in vitro as plastic-adherent cells, have fibroblast-like morphology, form colonies in vitro and can differentiate into bone, cartilage and fat cells. Recent studies have shown that MSCs can be differentiated into nonmesordermal lineages. Although MSCs can be isolated from every type of connective tissues, the abundance, the easy and repeatable access to subcutaneous adipose tissue and the simple isolation procedures indicate that adipose tissue can be a preferable candidate in MSC isolation for clinical application. Therefore, in this review, the isolation, characterization, preclinical and clinical application, and the mechanisms and future roles of ADSC in cell therapy are discussed.
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KEYWORD
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Adipose tissue, Mesenchymal stem cells, Differentiation, Clinical application, Cell therapy
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